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The Association of Altered Gut Microbiota and Intestinal Mucosal Barrier Integrity in Mice With Heroin Dependence.

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机构: [1]Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China, [2]Department ofClinical Laboratory, The First Affiliated Hospital of Kunming Medical University, Kunming, China, [3]Medical School, KunmingUniversity of Science and Technology, Kunming, China, [4]National Health Commission (NHC) Key Laboratory of DrugAddiction Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, China, [5]Centre for Experimental Studiesand Research, First Affiliated Hospital of Kunming Medical University, Kunming, China, [6]Department of GastrointestinalSurgery, The First Affiliated Hospital of Kunming Medical University, Kunming, China, [7]Department of Administrative Affairs,Yunnan University, Kunming, China
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关键词: heroin dependence gut microbiota intestinal mucosal barrier integrity SCFAs mice

摘要:
The gut microbiota is believed to play a significant role in psychological and gastrointestinal symptoms in heroin addicts. However, the underlying mechanism remains largely unknown. We show here that heroin addicts had a decrease in body mass index (BMI) and abnormal serum D-lactic acid (DLA), endotoxin (ET) and diamine oxidase (DAO) levels during their withdrawal stage, suggesting a potential intestinal injury. The gut microbial profiles in the mouse model with heroin dependence showed slightly decreased alpha diversity, as well as higher levels of Bifidobacterium and Sutterella and a decrease in Akkermansia at genus level compared to the control group. Fecal microbiota transplantation (FMT) further confirmed that the microbiota altered by heroin dependence was sufficient to impair body weight and intestinal mucosal barrier integrity in recipient mice. Moreover, short-chain fatty acids (SCFAs) profiling revealed that microbiota-derived propionic acid significantly decreased in heroin dependent mice compared to controls. Overall, our study shows that heroin dependence significantly altered gut microbiota and impaired intestinal mucosal barrier integrity in mice, highlighting the role of the gut microbiota in substance use disorders and the pathophysiology of withdrawal symptoms.Copyright © 2021 Yang, Xiong, Bai, Zhang, Zhou, Chen, Xie, Xu, Chen, Wang, Zhu, Yu and Wang.

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基金编号: s.3171101074,81870458,and 31860306

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出版当年[2022]版:
大类 | 2 区 农林科学
小类 | 2 区 营养学
最新[2023]版:
大类 | 2 区 农林科学
小类 | 3 区 营养学
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出版当年[2021]版:
Q1 NUTRITION & DIETETICS
最新[2023]版:
Q2 NUTRITION & DIETETICS

影响因子: 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

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第一作者机构: [1]Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China, [2]Department ofClinical Laboratory, The First Affiliated Hospital of Kunming Medical University, Kunming, China, [3]Medical School, KunmingUniversity of Science and Technology, Kunming, China, [4]National Health Commission (NHC) Key Laboratory of DrugAddiction Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, China,
通讯作者:
通讯机构: [1]Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China, [4]National Health Commission (NHC) Key Laboratory of DrugAddiction Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, China, [5]Centre for Experimental Studiesand Research, First Affiliated Hospital of Kunming Medical University, Kunming, China, [7]Department of Administrative Affairs,Yunnan University, Kunming, China
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