机构:[1]Department of Pathology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China.医技科室病理科昆明医科大学附属第一医院[2]Yunnan Key Laboratory of Pharmacology for Natural Products, School of Pharmaceutical Sciences, Kunming Medical University, Kunming 650500, China.
To explore the clinicopathological features of solitary fibrous tumors (SFTs) of the lung.We collected the clinical data of 52 patients with SFTs of the lung confirmed by pathology, and summarized the clinical, radiological, and morphological features, the immunophenotypes, and the prognosis of SFTs.Fifty-two cases of SFTs of the lung were enrolled in this study, including 51 cases of borderline and 1 case of malignancy, 22 males and 30 females. The average onset age was 52.7 years. The lower lobe of the left lung was the preferred site of SFTs, accounting for 30.77% (16/52). Chest CT showed regular and well-demarcated soft tissue density mass, and the tumor size of most cases (46/52, 88.46%) was 1-10 cm. Morphological features: The distribution of tumor cells showed sparse and dense areas. Tumor cells were spindle-shaped, in whorls or hemangiopericytoma-like conformation. Atypia, mitotic figures, and necrosis were found. Immunohistochemistry showed positive expression of CD34, STAT6, Vimentin, BCL2, and CD99. Ki-67 was ≤ 5% in borderline SFTs and >20% in a malignant SFT.Solitary fibrous tumors of the lung occur more frequently in middle-aged and elderly people, and there is no significant difference in gender. The lower lobe of the left lung is the preferred site of SFTs. The size of most SFTs is 1-10 cm. Chest CT shows morphologically regular and well-demarcated soft tissue density mass. Pathologically, SFTs of the lung are mostly borderline and occasionally malignant. Immunohistochemistry shows the positive expression of CD34, STAT6, Vimentin, BCL2, and CD99.
基金:
Joint Projects of Applied Basic Research of
Kunming Medical University and Yunnan Provincial Department of Science and Technology (No.
202101AY070001-010; No. 2019FE001-220).
第一作者机构:[1]Department of Pathology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China.
通讯作者:
推荐引用方式(GB/T 7714):
Wang Ying-Xia,Zhong Yan,Fan Su-Su,et al.Solitary Fibrous Tumors of the Lung: A Clinicopathological Analysis of 52 Cases[J].CURRENT ONCOLOGY.2023,30(2):1784-1793.doi:10.3390/curroncol30020138.
APA:
Wang Ying-Xia,Zhong Yan,Fan Su-Su,Zhu Yu-Shan,Peng Xue-Rong&Zhang Xuan.(2023).Solitary Fibrous Tumors of the Lung: A Clinicopathological Analysis of 52 Cases.CURRENT ONCOLOGY,30,(2)
MLA:
Wang Ying-Xia,et al."Solitary Fibrous Tumors of the Lung: A Clinicopathological Analysis of 52 Cases".CURRENT ONCOLOGY 30..2(2023):1784-1793