机构：[a]Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China外科科室骨科昆明医科大学附属第一医院[b]School of Materials Science and Engineering, Kunming University of Science and Technology, Kunming 650093, China[c]Department of Mechanical & Industrial Engineering, Northeastern University, Boston, Massachusetts 02115, United States[d]Department of Thoracic Surgery, The Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Kunming 650118, China
In this work, the modification of titanium surface with TiO2 nano-tubes (TNTs), and a solvent casting of biocompatible polymer (poly-DL-lactic acid) film combines gallium (III), as a factor of anti-inflammatory and bone resorption inhibitors, was assessed in the spinal infection rat model. Under in vitro condition, it is found that S. aureus and E. coli can attach and competitively survive on the TiO2 nano-tube surface and form the mixed bacteria biofilm. By contrasting the in vivo implantation of Cp Ti, TNTs and Ga-Cp Ti scaffolds, Ga-doped TNTs showed distinct and excellent anti-bacterial property and reduced inflammation and favorable compatibility with osteoblasts, which reveal a large potential of exploiting and modifying the multi-biofunction of implantable biomaterials. The described in vivo work expands the fundamental understanding of the advantages of gallium (III) and titania nano-array on antiresorptive and antimicrobial properties and the designing strategy of the composite coating is broadly applicable to a wide range of multifunctional biomaterials.
基金：
This work was jointly supported by the National Natural Science Foundation of China : the effect of Escherichia coli density regulating fac- tor QseC in biomaterials implantation ( 30872555 ) and Study on the ef- fect and mechanism of staphylococcal epidermidis-agrC specific binding polypeptide in the infection of cardiothoracic biomaterials (81460278).
第一作者机构：[a]Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China
通讯作者：
通讯机构：[*1]Department of Mechanical & Industrial Engineering, Northeastern University, Boston, Massachusetts 02115, United State.[*2]School of Materials Science and Engineering, Kunming University of Science and Technology, Kunming 650093, China.[*3]Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China[*4]Department of Thoracic Surgery, The Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Kunming, 650118, China.
推荐引用方式(GB/T 7714)：
Junjie Dong,Dong Fang,Lei Zhang,et al.Gallium-doped titania nanotubes elicit anti-bacterial efficacy in vivo against Escherichia coli and Staphylococcus aureus biofilm[J].MATERIALIA.2019,5:doi:10.1016/j.mtla.2019.100209.
APA：
Junjie Dong,Dong Fang,Lei Zhang,Quan Shan&Yunchao Huang.(2019).Gallium-doped titania nanotubes elicit anti-bacterial efficacy in vivo against Escherichia coli and Staphylococcus aureus biofilm.MATERIALIA,5,
MLA：
Junjie Dong,et al."Gallium-doped titania nanotubes elicit anti-bacterial efficacy in vivo against Escherichia coli and Staphylococcus aureus biofilm".MATERIALIA 5.(2019)
