机构：[1]Peking University Sixth Hospital, Beijing, China[2]Peking University Institute of Mental Health, Beijing, China[3]NHC Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China[4]The National Clinical Research Center for Mental Health Disorders (Peking University Sixth Hospital), Beijing, China[5]The Medical Psychological Research Center, Second Xiangya Hospital, Central South University, Changsha, Hunan, China[6]Division of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China[7]Xian Mental Health Center, New Qujiang District, Xian, Shanxi, China[8]Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China内科科室精神科昆明医科大学附属第一医院[9]The First Haerbin Psychiatric Hospital, Haerbin, Heilongjiang, China[10]Department of Psychiatry, University of California at San Diego, San Diego, CA, USA
Background: The MATRICS consensus cognitive battery (MCCB) has been widely used to evaluate cognitive deficits in schizophrenia (SCZ), however, no study has formally examined the validity of the MCCB in Chinese SCZ. This study compared Chinese SCZ patients with healthy Chinese controls on the MCCB and some additional neurocognitive tests to determine if the Chinese MCCB is an optimal battery to assess the cognitive deficits in Chinese SCZ patients. Method: The study enrolled and examined 230 patients met DSM-IV criteria for SCZ and 656 healthy controls matched for gender, age and education. Besides the MCCB, we also included some additional neurocognitive tests that have been widely used in patients with schizophrenia. We selected MCCB and non-MCCB tests with large effect size, to assemble a new "optimal battery" and compared its performance with that of the standard MCCB. Results: Comparing the putative "optimal" battery with the original MCCB, more patients with SCZ were identified as cognitively impaired according to the criteria of GDS >= 0.50 for the optimal battery (166 vs 135, or 72.2% vs 58.7%). The rate of cognitive impairment according to MCCB GDS in patients with SCZ who were currently working, ever worked and never worked are 45.5%, 61.6% and 70.8% (p = 0.051), whereas the optimal battery GDS showed 56.4%, 74.8%, 91.7% (p = 0.003), respectively. Conclusions: Our study needs validation with independent samples but suggests that the current "optimal" cognitive battery could be more sensitive than the widely used MCCB in detecting SCZ related cognitive impairment in China. (C) 2019 Elsevier B.V. All rights reserved.
基金：
Key Program of Beijing Science and Technology Commission [D171100007017002]; Capital Health Research and Development Fund [2016-3-4114]
第一作者机构：[1]Peking University Sixth Hospital, Beijing, China[2]Peking University Institute of Mental Health, Beijing, China[3]NHC Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China[4]The National Clinical Research Center for Mental Health Disorders (Peking University Sixth Hospital), Beijing, China
通讯作者：
通讯机构：[*1]Peking University Sixth Hospital, Beijing, China.
推荐引用方式(GB/T 7714)：
Shi Chuan,Kang Lan,Yao Shuqiao,et al.What is the optimal neuropsychological test battery for schizophrenia in China?[J].SCHIZOPHRENIA RESEARCH.2019,208:317-323.doi:10.1016/j.schres.2019.01.034.
APA：
Shi, Chuan,Kang, Lan,Yao, Shuqiao,Ma, Yibin,Li, Tao...&Yu, Xin.(2019).What is the optimal neuropsychological test battery for schizophrenia in China?.SCHIZOPHRENIA RESEARCH,208,
MLA：
Shi, Chuan,et al."What is the optimal neuropsychological test battery for schizophrenia in China?".SCHIZOPHRENIA RESEARCH 208.(2019):317-323
