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WWP2 Is One Promising Novel Oncogene

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收录情况： ◇ SCIE

作者：

机构： [1]Department of Thoracic Surgery, The Seventh People’s Hospital of Chengdu, Chengdu, Sichuan 640021, People’s Republic of China [2]School of Pharmacy, North Sichuan Medical College, Nanchong, Sichuan 637100, People’s Republic of China [3]Department of Respiratory Medicine, The People’s Hospital of Leshan, Leshan, Sichuan 640000, People’s Republic of China [4]Department of Pumnary and Critical Care Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, People’s Republic of China

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关键词： WWP2 Cancer Akt Pathogenesis

摘要：

WWP2 is an E3 ubiquitin ligase and plays an important role in regulation of many cellular biological activities through ubiquitination and degradation of its substrates. Recently accumulating evidences indicate that WWP2 plays a crucial part in the pathogenesis in different types of tumors. In this report, the role of this gene especially in tumorigenesis was reviewed. WWP2 is dysregulated in various of tumors, and it promotes carcinogenesis mainly through PTEN/Akt signaling pathway. WWP2 also participates in anti-cancer agents' sensitivity, indicating WWP2 may be a novel target for cancer treatment. WWP2 is one promising novel oncogene.

基金：

基金编号： -151

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出版当年[2020]版：

大类 | 3 区医学

小类 | 3 区病理学 4 区肿瘤学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区肿瘤学 4 区病理学

JCR分区：

出版当年[2019]版：

Q2 PATHOLOGY Q3 ONCOLOGY

最新[2023]版：

Q2 PATHOLOGY Q3 ONCOLOGY

影响因子： 2.3 最新[2023版] 2.4 最新五年平均 2.826 出版当年[2019版] 2.266 出版当年五年平均 2.433 出版前一年[2018版] 3.201 出版后一年[2020版]

第一作者：

第一作者机构： [1]Department of Thoracic Surgery, The Seventh People’s Hospital of Chengdu, Chengdu, Sichuan 640021, People’s Republic of China

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通讯作者：

通讯机构： [4]Department of Pumnary and Critical Care Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, People’s Republic of China

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